myeloid cells

[Nature Communications] Scientists used single-cell RNA sequencing analysis to delineate the immune landscape and tumor heterogeneity in a cohort of patients with HBV-associated human hepatocellular carcinoma.

[Journal of Immunology] Researchers performed a phenome-wide association study and reported that the T allele of GPR65-intronic single-nucleotide polymorphism rs8005161, which reduced GPR65 signaling, showed a significant association with atopic dermatitis, in addition to inflammatory bowel diseases and asthma, as previously reported.

[Science Advances] Investigators reported that m6A eraser AlkB homolog 5, but not FTO, maintained the ability of naïve CD4+ T cells to induce adoptive transfer colitis.

[Science Advances] The authors evaluated effects of >50 million single-nucleotide polymorphisms and short insertions/deletions provided by five inbred strains of mice on the responses of macrophages to interleukin-4 (IL-4), a cytokine that plays pleiotropic roles in immunity and tissue homeostasis.

[Biomaterials Science] Inspired by the specific neutrophil–endothelium interaction, investigators designed neutrophil-camouflaged magnetic nanoprobes that can be used to target activated endothelial cells for improved neuroinflammation imaging.

[Nature Communications] Investigators reported that Vpr counteracts lysosomal-associated transmembrane protein 5 (LAPTM5), a potent inhibitor of HIV-1 particle infectivity, to enhance HIV-1 infection in macrophages.