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Pulmonary Cell NewsInvestigators reported that Vpr counteracts lysosomal-associated transmembrane protein 5 (LAPTM5), a potent inhibitor of HIV-1 particle infectivity, to enhance HIV-1 infection in macrophages.
[Nature Communications]
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Zhao, L., Wang, S., Xu, M., He, Y., Zhang, X., Xiong, Y., Sun, H., Ding, H., Geng, W., Shang, H., & Liang, G. (2021). Vpr counteracts the restriction of LAPTM5 to promote HIV-1 infection in macrophages. Nature Communications, 12(1), 3691. https://doi.org/10.1038/s41467-021-24087-8 Cite
