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Pulmonary Cell NewsResearchers performed a phenome-wide association study and reported that the T allele of GPR65-intronic single-nucleotide polymorphism rs8005161, which reduced GPR65 signaling, showed a significant association with atopic dermatitis, in addition to inflammatory bowel diseases and asthma, as previously reported.
[Journal of Immunology]
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Xie, L., McKenzie, C. I., Qu, X., Mu, Y., Wang, Q., Bing, N., Naidoo, K., Alam, M. J., Yu, D., Gong, F., Ang, C., Robert, R., Marques, F. Z., Furlotte, N., Hinds, D., Gasser, O., Team, 23andMe Research, Xavier, R. J., & Mackay, C. R. (2021). pH and Proton Sensor GPR65 Determine Susceptibility to Atopic Dermatitis. The Journal of Immunology. https://doi.org/10.4049/jimmunol.2001363 Cite
