Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell NewsInspired by the specific neutrophil–endothelium interaction, investigators designed neutrophil-camouflaged magnetic nanoprobes that can be used to target activated endothelial cells for improved neuroinflammation imaging.
[Biomaterials Science]
6445218 EFLFG2RJ items 1 apa 0 default asc 1 163625 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-087835c075c50f020e3832fba61c8a8b%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22EFLFG2RJ%22%2C%22library%22%3A%7B%22id%22%3A6445218%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Tang%20et%20al.%22%2C%22parsedDate%22%3A%222021-06-02%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ETang%2C%20C.%2C%20Wang%2C%20Q.%2C%20Li%2C%20K.%2C%20Li%2C%20X.%2C%20Wang%2C%20C.%2C%20Xue%2C%20L.%2C%20Ju%2C%20C.%2C%20%26amp%3B%20Zhang%2C%20C.%20%282021%29.%20A%20neutrophil-mimetic%20magnetic%20nanoprobe%20for%20molecular%20magnetic%20resonance%20imaging%20of%20stroke-induced%20neuroinflammation.%20%3Ci%3EBiomaterials%20Science%3C%5C%2Fi%3E.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1039%5C%2FD1BM00566A%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1039%5C%2FD1BM00566A%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445218%26amp%3Bitem_key%3DEFLFG2RJ%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22A%20neutrophil-mimetic%20magnetic%20nanoprobe%20for%20molecular%20magnetic%20resonance%20imaging%20of%20stroke-induced%20neuroinflammation%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chunming%22%2C%22lastName%22%3A%22Tang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Qianqian%22%2C%22lastName%22%3A%22Wang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Kaiming%22%2C%22lastName%22%3A%22Li%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Xiuqi%22%2C%22lastName%22%3A%22Li%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Cong%22%2C%22lastName%22%3A%22Wang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lingjing%22%2C%22lastName%22%3A%22Xue%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Caoyun%22%2C%22lastName%22%3A%22Ju%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Can%22%2C%22lastName%22%3A%22Zhang%22%7D%5D%2C%22abstractNote%22%3A%22Neuroinflammation%20plays%20a%20key%20role%20in%20the%20progression%20of%20brain%20injury%20induced%20by%20stroke%2C%20and%20has%20become%20a%20promising%20target%20for%20therapeutic%20intervention%20for%20stroke.%20Monitoring%20this%20pivotal%20process%20of%20neuroinflammation%20is%20highly%20desirable%20to%20guide%20specific%20therapy.%20However%2C%20there%20is%20still%20a%20lack%20of%20a%20satisfactory%20nanoprobe%20to%20selectively%20monitor%20neuroinflammation.%20As%20endothelial%20cell%20activation%20is%20a%20hallmark%20of%20neuroinflammation%2C%20it%20would%20be%20clinically%20relevant%20to%20develop%20a%20non-invasive%20in%20vivo%20imaging%20technique%20to%20detect%20the%20endothelial%20activation%20process.%20Herein%2C%20inspired%20by%20the%20specific%20neutrophil%5Cu2013endothelium%20interaction%2C%20we%20designed%20neutrophil-camouflaged%20magnetic%20nanoprobes%20%28NMNPs%29%20that%20can%20be%20used%20to%20target%20activated%20endothelial%20cells%20for%20improved%20neuroinflammation%20imaging.%20NMNPs%20are%20composed%20of%20an%20inner%20core%20of%20superparamagnetic%20iron%20oxide%20%28SPIO%29-loaded%20poly%28lactic-co-glycolic%20acid%29%20%28PLGA%29%20nanoparticles%20and%20a%20biomimetic%20outer%20shell%20of%20a%20neutrophil%20membrane%2C%20which%20maintained%20the%20biocompatibility%20and%20targeting%20ability%20of%20neutrophils%20and%20the%20excellent%20contrast%20effects%20of%20SPIO.%20Moreover%2C%20we%20demonstrated%20that%20NMNPs%20can%20successfully%20bind%20to%20inflamed%20cerebral%20vasculature%20using%20the%20intravital%20imaging%20of%20live%20cerebral%20microvessels%20in%20transient%20middle%20cerebral%20artery%20occlusion%20%28tMCAO%29%20mice.%20After%20that%2C%20NMNPs%20could%20further%20accumulate%20in%20the%20brain%20vasculature%20and%20exhibit%20excellent%20contrast%20effects%20for%20stroke-induced%20neuroinflammation%20and%20biosafety.%20We%20believe%20that%20the%20neutrophil-camouflaged%20magnetic%20nanoprobe%20could%20serve%20as%20a%20highly%20safe%20and%20selective%20nanoprobe%20for%20neuroinflammation%20imaging%20and%20has%20alluring%20prospects%20for%20clinical%20application.%22%2C%22date%22%3A%222021-06-02%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1039%5C%2FD1BM00566A%22%2C%22ISSN%22%3A%222047-4849%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fpubs.rsc.org%5C%2Fen%5C%2Fcontent%5C%2Farticlelanding%5C%2F2021%5C%2Fbm%5C%2Fd1bm00566a%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-06-18T21%3A32%3A12Z%22%7D%7D%5D%7D
Tang, C., Wang, Q., Li, K., Li, X., Wang, C., Xue, L., Ju, C., & Zhang, C. (2021). A neutrophil-mimetic magnetic nanoprobe for molecular magnetic resonance imaging of stroke-induced neuroinflammation. Biomaterials Science. https://doi.org/10.1039/D1BM00566A Cite
