myeloid cells

[Communications Biology] Researchers used a humanized mouse model to show that while carboplatin plus pembrolizumab reduced tumor growth moderately and transiently, the addition of the tumor suppressor gene TUSC2, delivered systemically in nanovesicles, to this combination, eradicates tumors in the majority of animals.

[Journal of Cellular and Molecular Medicine] Exposure of lung epithelial and endothelial cells to nitrogen mustard led to intracellular oxidative stress that compromised the intrinsic cell membrane repair function of MG53.

[Journal of Experimental & Clinical Cancer Research] The authors demonstrated that enhanced secretory autophagy in glioblastoma (GB) facilitated M1-like polarization of tumor associated macrophages to enhance temozolomide sensitivity of GB cells.

[Nature Reviews Neurology] The authors provide an overview of the involvement of astrocytes and microglia at major sites of pathology in progressive multiple sclerosis.

[Glia] Scientists identified the underlying mechanism and showed that microglial morphology and functions were already impaired during glioma initiation stages.

[EMBO Journal] Scientists showed that the serine/threonine kinase AKT2 interacted with interferon regulatory factor 3 (IRF3) and phosphorylated it on Thr207, thereby attenuating IRF3 nuclear translocation in a 14-3-3ε-dependent manner and reducing induced type I interferon production.