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myeloid cells

Monocytes Transition to Macrophages within the Inflamed Vasculature via Monocyte CCR2 and Endothelial TNFR2

[Journal of Experimental Medicine] Investigators showed that monocytes acquired macrophage markers upon glomerulonephritis and may have been derived from CCR2+CX3CR1+ double-positive monocytes, which were preferentially recruited, dwelled within glomerular capillaries, and acquired proinflammatory characteristics in the nephritic kidney.

Ubiquitin-Like Protein 3 (UBL3) Is Required for MARCH Ubiquitination of Major Histocompatibility Complex Class II and CD86

[Nature Communications] Researchers showed, using a genome-wide CRISPR knockout screen, that UBL3 was a necessary component of ubiquitination-mediated trafficking of major histocompatibility complex class II and CD86 in mice and in humans.

Myeloid Cell PKM2 Deletion Enhances Efferocytosis and Reduces Atherosclerosis

[Circulation Research] Genetic deletion of pyruvate kinase muscle 2 (PKM2) in myeloid cells or limiting its nuclear translocation reduced atherosclerosis by suppressing inflammation and enhancing efferocytosis.

CCR2/CCR5 Inhibitor Permits the Radiation-Induced Effector T Cell Infiltration in Pancreatic Adenocarcinoma

[Journal of Experimental Medicine] Using PDAC mouse models, scientists demonstrated that radiation therapy followed by anti-PD-1 antibody and prolonged treatment with CCR2/5i conferred better antitumor efficacy than other combination treatments tested.

Single-Cell Characterization of Leukemic and Non-Leukemic Immune Repertoires in CD8+ T Cell Large Granular Lymphocytic Leukemia

[Nature Communications] Utilizing single-cell RNA and T cell receptor profiling, researchers showed that irrespective of STAT3 mutation status, T cell large granular lymphocytic leukemia clonotypes were more cytotoxic and exhausted than healthy reactive clonotypes.

Monocytes Transition to Macrophages within the Inflamed Vasculature via Monocyte CCR2 and Endothelial TNFR2

[Journal of Experimental Medicine] Investigators showed that monocytes acquired macrophage markers upon glomerulonephritis and may have been derived from CCR2+CX3CR1+ double-positive monocytes, which were preferentially recruited, dwelled within glomerular capillaries, and acquired proinflammatory characteristics in the nephritic kidney.

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