Resolvin D1 Supports Skeletal Myofiber Regeneration via Actions on Myeloid and Muscle Stem Cells

Scientists profiled intramuscular lipid mediators via liquid chromatography-tandem mass spectrometry–based metabolipidomics following myofiber injury and investigated the potential role of specialized proresolving mediators in skeletal muscle inflammation and repair.
[JCI Insight]
Markworth, J. F., Brown, L. A., Lim, E., Floyd, C., Larouche, J., Castor-Macias, J. A., Sugg, K. B., Sarver, D. C., Macpherson, P. C. D., Davis, C., Aguilar, C. A., Maddipati, K. R., & Brooks, S. V. (2020). Resolvin D1 supports skeletal myofiber regeneration via actions on myeloid and muscle stem cells. JCI Insight, 5(18). https://doi.org/10.1172/jci.insight.137713 Cite
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Keratinocyte Autophagy Enables the Activation of Keratinocytes and Fibroblasts and Facilitates Wound Healing

Using cytokine array screening, scientists found that autophagy deficiency inhibited the transcription and production of the cytokine CCL2/MCP-1 by TNF.
[Autophagy]
Qiang, L., Yang, S., Cui, Y.-H., & He, Y.-Y. (2020). Keratinocyte autophagy enables the activation of keratinocytes and fibroblasts and facilitates wound healing. Autophagy, 0(0), 1–16. https://doi.org/10.1080/15548627.2020.1816342 Cite
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Sarcoidosis Exosomes Stimulate Monocytes to Produce Pro-Inflammatory Cytokines and CCL2

The authors found that bronchoalveolar lavage fluid exosomes from sarcoidosis patients, but not from healthy individuals, induced a dose-dependent elevation of intracellular IL-1β in monocytes.
[Scientific Reports]
Wahlund, C. J. E., Gucluler Akpinar, G., Steiner, L., Ibrahim, A., Bandeira, E., Lepzien, R., Lukic, A., Smed-Sörensen, A., Kullberg, S., Eklund, A., Grunewald, J., & Gabrielsson, S. (2020). Sarcoidosis exosomes stimulate monocytes to produce pro-inflammatory cytokines and CCL2. Scientific Reports, 10(1), 15328. https://doi.org/10.1038/s41598-020-72067-7 Cite
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Downregulation of the CCL2/CCR2 and CXCL10/CXCR3 Axes Contributes to Antitumor Effects in a Mouse Model of Malignant Glioma

Scientists studied the importance of paracrine signaling in the glioma microenvironment by focusing on the celecoxib-mediated role of chemokines C–C motif ligand 2, C-X-C ligand 10, and their receptors, CCR2 and CXCR3, in glioma stem cells (GSCs) and a GSC-bearing malignant glioma model.
[Scientific Reports]
Shono, K., Yamaguchi, I., Mizobuchi, Y., Kagusa, H., Sumi, A., Fujihara, T., Nakajima, K., Kitazato, K. T., Matsuzaki, K., Saya, H., & Takagi, Y. (2020). Downregulation of the CCL2/CCR2 and CXCL10/CXCR3 axes contributes to antitumor effects in a mouse model of malignant glioma. Scientific Reports, 10(1), 15286. https://doi.org/10.1038/s41598-020-71857-3 Cite
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Exosome-Mediated Crosstalk between Keratinocytes and Macrophages in Cutaneous Wound Healing

Investigators elucidated the significance of exosome in keratinocyte-macrophage crosstalk following injury.
[ACS Nano]
Zhou, X., Brown, B. A., Siegel, A. P., El Masry, M., Zeng, X., Song, W., Das, A., Khandelwal, P., Clark, A., Singh, K., Guda, P. R., Gorain, M., Timsina, L., Xuan, Y., Jacobson, S. C., Novotny, M. V., Roy, S., Agarwal, M., Lee, R. J., … Ghatak, S. (2020). Exosome-Mediated Crosstalk between Keratinocytes and Macrophages in Cutaneous Wound Healing. ACS Nano. https://doi.org/10.1021/acsnano.0c03064 Cite
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Activation of Proprotein Convertase in the Mouse Habenula Causes Depressive-Like Behaviors through Remodeling of Extracellular Matrix

Scientists found that chronic social defeat stress increased production of pro-inflammatory cytokines in lateral habenula associated with mobilization of monocytes and remodeling of extracellular matrix by increased matrix metalloproteinase activity.
[Neuropsychopharmacology]
Ito, H., Nozaki, K., Sakimura, K., Abe, M., Yamawaki, S., & Aizawa, H. (2020). Activation of proprotein convertase in the mouse habenula causes depressive-like behaviors through remodeling of extracellular matrix. Neuropsychopharmacology, 1–14. https://doi.org/10.1038/s41386-020-00843-0 Cite
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The Influenza Virus NS1A Binding Protein Gene Modulates Macrophages Response to Cytokines and Phagocytic Potential in Inflammation

The authors determined that the modulation of the Ivns1abp gene in macrophages could modify resistance to macrophages against inflammation and maintain functional phagocytosis.
[Scientific Reports]
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Tumor-Derived HMGB1 Induces CD62Ldim Neutrophil Polarization and Promotes Lung Metastasis in Triple-Negative Breast Cancer

Investigators observed that high mobility group box 1 protein (HMGB1) was highly expressed in human TNBC and positively correlated with cancer metastasis.
[Oncogenesis]
Wang, Z., Yang, C., Li, L., Jin, X., Zhang, Z., Zheng, H., Pan, J., Shi, L., Jiang, Z., Su, K., Li, B., Shao, X., Qiu, F., Yan, J., & Huang, J. (2020). Tumor-derived HMGB1 induces CD62L dim neutrophil polarization and promotes lung metastasis in triple-negative breast cancer. Oncogenesis, 9(9), 1–17. https://doi.org/10.1038/s41389-020-00267-x Cite
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Hypoxia-Inducible Factor α Subunits Regulate Tie2-Expressing Macrophages That Influence Tumor Oxygen and Perfusion in Murine Breast Cancer

Because of the hypoxic nature of solid tumors, researchers investigated if oxygen, via hypoxia-inducible transcription factors HIF-1α and HIF-2α, regulated tie2-expressing monocytes/macrophages function in the hypoxic tumor microenvironment.
[Journal of Immunology]
Steinberger, K. J., Forget, M. A., Bobko, A. A., Mihalik, N. E., Gencheva, M., Roda, J. M., Cole, S. L., Mo, X., Hoblitzell, E. H., Evans, R., Gross, A. C., Moldovan, L., Marsh, C. B., Khramstov, V. V., & Eubank, T. D. (2020). Hypoxia-Inducible Factor α Subunits Regulate Tie2-Expressing Macrophages That Influence Tumor Oxygen and Perfusion in Murine Breast Cancer. The Journal of Immunology. https://doi.org/10.4049/jimmunol.2000185 Cite
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Xeno-Free Condition Enhances Therapeutic Functions of Human Wharton’s Jelly-Derived Mesenchymal Stem Cells against Experimental Colitis by Upregulated Indoleamine 2,3-Dioxygenase Activity

Researcchers extensively compared the physiological functions of human Wharton’s jelly-derived mesenchymal stem cells in a xeno-free medium and a medium containing 10% fetal bovine serum.
[Journal of Clinical Medicine]
Kang, J. Y., Oh, M.-K., Joo, H., Park, H. S., Chae, D.-H., Kim, J., Lee, H.-R., Oh, I.-H., & Yu, K.-R. (2020). Xeno-Free Condition Enhances Therapeutic Functions of Human Wharton’s Jelly-Derived Mesenchymal Stem Cells against Experimental Colitis by Upregulated Indoleamine 2,3-Dioxygenase Activity. Journal of Clinical Medicine, 9(9), 2913. https://doi.org/10.3390/jcm9092913 Cite
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Biomimetic 3D Models for Investigating the Role of Monocytes and Macrophages in Atherosclerosis

Scientists utilized three-dimensional collagen matrices that allowed them to mimic the ECM stiffening during atherosclerosis by increasing collagen density.
[Bioengineering]
Garcia-Sabaté, A., Mohamed, W. K. E., Sapudom, J., Alatoom, A., Al Safadi, L., & Teo, J. C. M. (2020). Biomimetic 3D Models for Investigating the Role of Monocytes and Macrophages in Atherosclerosis. Bioengineering, 7(3), 113. https://doi.org/10.3390/bioengineering7030113 Cite
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