NOX1 Mediates Metabolic Heart Disease in Mice and Is Upregulated in Monocytes of Humans with Diastolic Dysfunction

NOX1 mediated endothelial activation and contributed to myocardial inflammation and remodeling in metabolic disease in mice. Given its high expression in monocytes of humans with diastolic dysfunction (DD), NOX1 may represent a potential target to mitigate heart disease associated with DD.
[Cardiovascular Research]
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Novel Combination of Bioactive Agents in Bilayered Dermal Patches Provides Superior Wound Healing

Multifunctional bilayered dermal patches with antibacterial, antioxidant and anti-inflammatory properties were developed and compared for performance. Soluble eggshell membrane protein improved migration of human adult dermal fibroblasts, suggesting its contribution to wound healing.
[Nanomedicine-Nanotechnology Biology and Medicine]
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Sorafenib Attenuates Liver Fibrosis by Triggering Hepatic Stellate Cell Ferroptosis via HIF-1α/SLC7A11 Pathway

Scientists investigate the functional role of hepatic stellate cell ferroptosis in the anti-fibrotic effect of sorafenib and found that sorafenib attenuated liver injury and extracellular matrix accumulation in CCl4-induced fibrotic livers, accompanied by reduction of SLC7A11 and GPX4 proteins.
[Cell Proliferation]
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Long Non-Coding RNA HOMER3-AS1 Drives Hepatocellular Carcinoma Progression via Modulating the Behaviors of Both Tumor Cells and Macrophages

The authors identified a lncRNA, HOMER3-AS1, which was over-expressed in hepatocellular carcinoma (HCC) and correlated with poor survival of HCC patients. HOMER3-AS1 promoted HCC cellular proliferation, migration, and invasion, and reduced HCC cellular apoptosis.
[Cell Death & Disease]
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Remimazolam Reduces Sepsis-Associated Acute Liver Injury by Activation of Peripheral Benzodiazepine Receptors and p38 Inhibition of Macrophages

The authors showed that remimazolam could attenuate inflammatory response in sepsis-associated acute liver injury, which may have been associated with activation of peripheral benzodiazepine receptors and inhibition of p38 phosphorylation in macrophages.
[International Immunopharmacology]
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Liver Ischaemia–Reperfusion Injury: A New Understanding of the Role of Innate Immunity

Scientists summarize the role of macrophages, platelets and neutrophils in liver ischaemia–reperfusion injury (LIRI), highlight unanswered questions, and discuss prospects for innovative therapeutic regimens against LIRI in transplant recipients.
[Nature Reviews Gastroenterology & Hepatology]
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Interrogation of the Microenvironmental Landscape in Spinal Ependymomas Reveals Dual Functions of Tumor-Associated Macrophages

Scientists performed single-cell RNA-sequencing analysis of three spinal ependymoma subtypes to dissect the microenvironmental landscape of spinal ependymomas and revealed tumor-associated macrophage subsets with distinct functional phenotypes.
[Nature Communications]
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High Endogenous CCL2 Expression Promotes the Aggressive Phenotype of Human Inflammatory Breast Cancer

Researchers described a human inflammatory breast cancer (IBC) cell line, A3250, that recapitulated key IBC features in a mouse xenograft model, including skin erythema, diffuse tumor growth, dermal lymphatic invasion, and extensive metastases.
[Nature Communications]
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NogoA-Expressing Astrocytes Limit Peripheral Macrophage Infiltration after Ischemic Brain Injury in Primates

Utilizing single-nuclei transcriptomics to characterize astrocytes after ischemic stroke in the visual cortex of the marmoset monkey, researchers observed nearly complete segregation between stroke and control astrocyte clusters.
[Nature Communications]
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Delayed Fractional Dosing with RTS, S/AS01 Improves Humoral Immunity to Malaria via a Balance of Polyfunctional NANP6- and Pf16-Specific Antibodies

The authors demonstrated that the delayed fractional dose maintained monocyte phagocytosis and NK activation mediated by NANP6-specific antibodies, key correlates of protection for the RTS,S/AS01 doses regimen.
[Med]
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Transcriptional Control of Gene Expression and the Heterogeneous Cellular Identity of Erythroblastic Island Macrophages

Recent studies focus on bulk and single cell transcriptomics of the island macrophage during adult steady-state erythropoiesis and embryonic erythropoiesis.
[Frontiers in Genetics]
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