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myeloid cells

Emerging Concepts of Vascular Cell Clonal Expansion in Atherosclerosis

[Arteriosclerosis Thrombosis and Vascular Biology] Scientists discuss key findings from the latest research that give insight into the mechanisms by which clonal expansion of vascular cells contributes to disease pathology.

The Induction of Peripheral Trained Immunity in the Pancreas Incites Anti-tumor Activity to Control Pancreatic Cancer Progression

[Nature Communications] Scientists demonstrated that yeast-derived particulate β-glucan, an inducer of trained immunity, trafficed to the pancreas, which caused a CCR2-dependent influx of monocytes/macrophages to the pancreas that display features of trained immunity.

Single-Cell RNA Sequencing Reveals Induction of Distinct Trained Immunity Programs in Human Monocytes

[Journal of Clinical Investigation] Researchers demonstrated cellular transcriptional programs to four different inducers of trained immunity in monocyte populations at single-cell resolution.

Recombinant Lloviu Virus as a Tool to Study Viral Replication and Host Responses

[PLoS Pathogens] Similar to other filoviruses, recombinant Lloviu virus formed filamentous virions and induced the formation of characteristic inclusions in the cytoplasm of the infected cells, as shown by electron microscopy.

Enhancing Endocannabinoid Signaling in Astrocytes Promotes Recovery from Traumatic Brain Injury

[Brain] Scientists revealed a previously undefined cell type-specific role of 2-arachidonoylglycerol metabolism and signaling pathways in traumatic brain injury-induced neuropathology.

Targeting Macrophages for Enhancing CD47 Blockade-Elicited Lymphoma Clearance and Overcoming Tumor-Induced Suppression

[Blood] The authors showed that late-stage Non-Hodgkin's Lymphoma was resistant to therapy targeting phagocytosis checkpoint CD47, due to the compromised capacity of tumor-associated macrophages to phagocytose lymphoma cells.

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