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myeloid cells

Unique Molecular and Functional Features of Extramedullary Hematopoietic Stem and Progenitor Cell Reservoirs in Humans

[Blood] Researchers comprehensively delineated human extramedullary hematopoietic stem and progenitor cell compartments comparing spleen, peripheral blood (PB) and mobilized PB (mPB) to bone marrow using single-cell RNA-seq and/or functional assays.

Cathepsin S Contributes to Lung Inflammation in Acute Respiratory Distress Syndrome

[American Journal of Respiratory and Critical Care Medicine] Human and mouse model bronchoalveolar lavage fluid samples were analyzed for the presence and activity of cathepsin S and its endogenous inhibitors.

Pan-Cancer Analysis of GALNTs Expression Identifies a Prognostic of GALNTs Feature in Low Grade Glioma

[Journal of Leukocyte Biology] Investigators used Oncomine and The Cancer Genome Atlas databases to analyze the transcription and survival effect of N-acetylgalactosaminyltransferase genes (GALNTs) in pan-cancer.

Constructing a Novel Signature Based on Immune-Related lncRNA to Improve Prognosis Prediction of Cervical Squamous Cell Carcinoma Patients

[Reproductive Sciences] Researchers assessed the correlation between immune infiltration status, chemotherapeutics sensitivity, immune checkpoint proteins, and the signature.

NLRP3 Inflammasome Activation in Human Peripheral Blood Mononuclear Cells Induced by Venoms Secreted PLAM2s

[International Journal of Biological Macromolecules] Peripheral blood mononuclear cells were isolated by density gradient and incubated with RPMI, LPS, BthTX-I or BthTX-II isolated from Bothrops jararacussu venom, to evaluate viability, and the results showed that there was no cell death.

LRG1: An Emerging Player in Disease Pathogenesis

[Journal of Biomedical Science] Emphasis is given to the role that leucine-rich α-2 glycoprotein 1 (LRG1) plays as a vasculopathic factor where it disrupts the cellular interactions normally required for the formation and maintenance of mature vessels, thereby indirectly contributing to the establishment of a highly hypoxic and immunosuppressive microenvironment.

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