myeloid cells

[British Journal of Cancer] The authors present a few actionable steps for basic, translational and clinical research communities in advancing the utility of the platelet transcriptome as a highly sensitive biomarker in cancer and collectively enable efforts toward clinical translation and patient benefit.

[Cancer Immunology Research] Transcriptome analysis revealed that B7-H3 was highly expressed in PD-L1-low, non-immunoreactive high-grade serous ovarian cancer tumors, and its expression negatively correlated with an IFNγ signature, which reflected the tumor immune-reactivity.

[Cancer Research] Emerging evidence indicates B cell activating factor (BAFF) to be an important cytokine for anti-tumor immunity. The authors generated a BAFF-overexpressing B16.F10 melanoma cell model and found that BAFF-expressing tumors grew more slowly in vivo than control tumors.

[Journal of Ethnopharmacology] The authors investigated the wound healing potential of okra fruit by in vitro and in vivo experimental models. The biocompatibility of the gel formulations prepared with the best performing extract were evaluated by human Epiderm™ reconstituted skin irritation test model.

[Cellular & Molecular Immunology] Agonist-induced stimulator of interferon genes (STING) signaling activation in macrophages was revealed to inhibit covalently closed circular DNA-mediated transcription and hepatitis B virus (HBV) replication via epigenetic modification in hepatocytes.

[NPG Asia Materials] 3D printed macrophage exosomes scaffolds, exhibiting a predefined structure and persistent release of exosomes, displayed distinct immunomodulatory effects and improved osteogenesis/angiogenesis.