myeloid cells

[Laboratory Investigation] Researchers demonstrated that lipopolysaccharide promoted c-Jun N-terminal kinase signaling pathway activation and endogenous tumor necrosis factor-α secretion in pulmonary macrophages.

[Science Translational Medicine] Researchers found that the cytokine oncostatin M was highly up-regulated in psoriasis, atopic dermatitis, and cutaneous T cell lymphoma, diseases associated with chronic itch.

[Cell Death & Disease] By exposing bEnd.3 endothelial cells and primary cortical neurons to oxygen−glucose deprivation (OGD), the impact of extracellular vesicles from OGD-preconditioned microglia on angiogenesis and neuronal apoptosis by the tube formation assay and TUNEL staining was assessed.

[Nature Reviews Cardiology] Investigators highlight efforts to develop imaging techniques and to therapeutically manipulate macrophages in atherosclerotic plaques with the use of rationally designed nanoparticles, and review the latest progress in nanoparticle-based imaging modalities that can specifically target macrophages.

[Scientific Reports] Investigators found that elastolysis of elastic fibers and collagen accumulation contributed to vascular stiffening and arterial hypertension. Therefore, apelin expression could be a major element to preserve vascular homeostasis.

[Laboratory Investigation] Based on the immunohistochemical analysis of breast cancer tissues from 497 patients, the authors demonstrated that matrix metalloproteinase 11 (MMP11) expression in mononuclear inflammatory cells was an independent negative prognostic factor in breast cancer, whereas MMP11 expression in tumor cells and fibroblasts was not associated with patient survival.