Natural Killer Cells

[Cancer Research] To understand the different facets of immune-tumor collaboration through genetics, spatial transcriptomics, and immunological manipulation with non-invasive, longitudinal imaging, the authors generated a penetrant double oncogene-driven autochthonous model of neuroblastoma.

[Journal of Experimental Medicine] Scientists review the interactions between immune cells and astrocytes and their roles in health and neurological diseases, with a special focus on multiple sclerosis.

[Journal of Clinical Investigation] In mice, lack of PTPN22 augmented antitumor activity with greater infiltration and activation of macrophages, natural killer (NK) cells, and T cells.

[Journal of Leukocyte Biology] miRNA profiles were evaluated and eight miRNAs were found to be differentially expressed in patient-derived cell lines in comparison to controls. miR-181c was predicted to target myeloid cell leukemia (MCL)1, which was confirmed by transfection assays, resulting in significantly reduced MCL1 mRNA and decreased live cell numbers.

[Proceedings of the National Academy of Sciences of the United States of America] In humans, JAK3 and γc deficiencies resulted in severe combined immunodeficiency characterized by an absence of T cells, natural killer cells, innate lymphoid cells, and presumably lymphoid tissue inducer cells.

[Journal of Immunology] Scientists defined differences in cortical actin content associated with differential expression of actin regulating proteins, suggesting that differences in adhesome expression were associated with differences in cortical actin homeostasis.