miR-181c Regulates MCL1 and Cell Survival in GATA2 Deficient Cells

miRNA profiles were evaluated and eight miRNAs were found to be differentially expressed in patient-derived cell lines in comparison to controls. miR-181c was predicted to target myeloid cell leukemia (MCL)1, which was confirmed by transfection assays, resulting in significantly reduced MCL1 mRNA and decreased live cell numbers.