neural cells

[Cancer Letters] Scientists identified the gene amplification and protein overexpression of HOXA5 in glioma stem cells (GSCs) and its function in regulating GSC maintenance and the downstream transcriptional effector, to explore the significance of HOXA5 amplification/overexpression for GSC identification and prognostic determination.

[Molecular Oncology] The glioblastoma tumoral mass was characterized by a small cellular subpopulation, glioblastoma stem cells that has been held responsible for glioblastoma initiation, cell invasion, proliferation, relapse and resistance to chemo and radiotherapy.

[Pathology Research and Practice] Investigators draw an interaction map for glioblastomas (GBMs) and promote awareness of the complexity of the GBM microenvironment.

[Scientific Reports] Researchers conducted a library screening to quantify amyloid β and neuronal toxicity by using cortical neurons from hiPSCs of AD patients after adding secondary metabolites.

[Scientific Reports] Nine compounds demonstrated desirable glioblastoma cell toxicity in cell culture, and two of them, HR51, and HR59 demonstrated significantly improved capability of crossing the model blood–brain-barrier composed of endothelial cells, astrocytes and pericytes.

[Nature] Loss of TDP-43 from the nucleus in human brain, neuronal cell lines and motor neurons derived from induced pluripotent stem cells resulted in the inclusion of a cryptic exon in UNC13A mRNA and reduced UNC13A protein expression.