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neural cells

Caught in Vicious Circles: A Perspective on Dynamic Feed-Forward Loops Driving Oxidative Stress in Schizophrenia

[Molecular Psychiatry] Scientists review the existing experimental and translational research pinpointing the complex dynamics of oxidative stress mechanisms and their modulation in relation to schizophrenia pathophysiology.

Biomaterials Patterning Regulates Neural Stem Cells Fate and Behavior: The Interface of Biology and Material Science

[Journal of Biomedical Materials Research Part A] Investigators discuss how the physical and biochemical properties of biomaterials, such as their stiffness and elasticity, could influence the behavior of neural stem cells.

Novel Cancer Stem Cell Marker MVP Enhances Temozolomide-Resistance in Glioblastoma

[Translational Oncology] Researchers found that sensitivity toTemozolomide (TMZ) was suppressed by significantly increasing the major vault protein (MVP) expression in glioblastoma multiforme cells with TMZ resistance.

Improving Motor Neuron-Like Cell Differentiation of hEnSCs by the Combination of Epothilone B Loaded PCL Microspheres in Optimized 3D Collagen Hydrogel

[Scientific Reports] Providing a 3D permissive environment with epothilone B significantly improved motor neuron-like cell differentiation and maturation of human endometrial stem cells (hEnSCs) and was a promising approach to replace lost neurons after spinal cord injury.

Direct Conversion of Cell Fate and Induced Endothelial Cells

[Circulation Journal] Researchers suggest that careful assessment of the status of converted cells using genetic and epigenetic profiling, various functional assays, and the use of multiple readouts is essential to determine successful conversion.

Generation of Skin Organoids: Potential Opportunities and Challenges

[Frontiers in Cell and Developmental Biology] Investigators summarize the current literatures relating to the “niches” of the local skin stem cell microenvironment and the formation of skin organoids, and discuss the opportunities and challenges associated with multifunctional skin organoids.

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