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neural cells

Low Temperature Plasma Irradiation Products of Sodium Lactate Solution That Induce Cell Death on U251SP Glioblastoma Cells Were Identified

[Scientific Reports] Scientists quantified several major chemical products, such as pyruvate, formate, and acetate, in plasma-activated L-sodium lactate solution by nuclear magnetic resonance analysis.

The Transcription Factor BCL11A Defines Distinct Subsets of Midbrain Dopaminergic Neurons

[Cell Reports] Researchers showed that the transcription factor BCL11A was expressed in a subset of midbrain dopaminergic (mDA) neurons in the developing and adult murine brain and in a subpopulation of pluripotent-stem-cell-derived human mDA neurons.

Adenosine A2A Receptor Activation Enhances Blood-Tumor Barrier Permeability in a Rodent Glioma Model

[Molecular Cancer Research] Researchers characterized the time-dependent impact of regadenoson on brain endothelial cell interactions and paracellular transport, using mouse and rat brain endothelial cells and tumor models.

circFLNA Promotes Glioblastoma Proliferation and Invasion by Negatively Regulating miR-199-3p Expression

[Molecular Medicine Reports] Researchers aimed to identify differentially expressed circular RNAs in glioblastoma. Reverse transcription‑quantitative PCR was used to analyze the expression levels of circFLNA.

Defining the Nature of Human Pluripotent Stem Cell-Derived Interneurons via Single-Cell Analysis

[Stem Cell Reports] Researchers applied single-nuclei and single-cell transcriptomics to model interneuron development from human cortex and interneurons derived from PSCs, and provided a direct comparison of various in vitro interneuron derivation methods to determine the homogeneity achieved.

Thermosensitive Collagen/Fibrinogen Gels Loaded with Decorin Suppress Lesion Site Cavitation and Promote Functional Recovery after Spinal Cord Injury

[Scientific Reports] Scientists reported the development of a novel, flowable, thermosensitive, injectable drug delivery system comprising bovine collagen (BC) and fibrinogen (FB) that formed a solid BC/FB gel immediately upon exposure to physiological conditions and could be used to deliver reparative drugs, such as the naturally occurring anti-inflammatory, anti-scarring agent Decorin, into adult rat spinal cord lesion sites.

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