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neural cells

MiR-124 Synergism with ELAVL3 Enhances Target Gene Expression to Promote Neuronal Maturity

[Proceedings of the National Academy of Sciences of the United States of America] Here, we identified targets of miR-9/9*-124 as reprogramming cells activate the neuronal program and reveal the role of miR-124 that directly promotes the expression of its target genes associated with neuronal development and function.

Ndufs4 Ablation Decreases Synaptophysin Expression in Hippocampus

[Scientific Reports] Researchers silenced Ndufs4 in Neuro-2a cells and we observed shorter neurite lengths with decreased expression of synaptophysin.

Present State and Future Perspectives of Prostaglandins as a Differentiation Factor in Motor Neurons

[Cellular and Molecular Neurobiology] Researchers discuss the potential of prostaglandins as candidates for the development of new therapeutic drugs for motor neuron diseases.

Blood-Brain Barrier Dysfunction as a Potential Therapeutic Target for Neurodegenerative Disorders

[Archives of Pharmacal Research] We herein review a potential role of the major cellular components of the blood-brain barrier (BBB), with a focus on the contribution of BBB disruption, in neurodegenerative disease progression.

Novo Nordisk Prize for Research on Novel Therapeutic Approaches for Brain Disease

[University of Freiburg (EurekAlert!)] As wardens and housekeepers, the microglia play a central role in both monitoring and defending the brain and maintaining its normal functions. At the start of his career, German professor Marco Prinz became fascinated by these cells, which were at that time primarily thought to be the brain's garbage collectors.

Co-Development of Central and Peripheral Neurons with Trunk Mesendoderm in Human Elongating Multi-Lineage Organized Gastruloids

[Nature Communications] Researchers evaluate elongating multi-lineage organized over a 40 day period, applying immunofluorescence of multi-lineage and functional biomarkers, including day 16 single-cell RNA-Seq, and evaluation of ectodermal and non-ectodermal neural crest cells.

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