neural stem cells

[Cells] Investigators developed a protocol enabling a derivation of MSC subpopulation with increased expression of pluripotent and neural genes.

[PLoS Biology] The authors investigated the hypothesis that neural stem cells release and traffic functional mitochondria via extracellular vesicles to restore mitochondrial function in target cells.

[Cell Stem Cell] The authors combined dynamic imaging of entire neural stem cell (NSC) populations in their in vivo niche over several weeks with pharmacological manipulations, mathematical modeling, and spatial statistics and demonstrated that NSCs use spatiotemporally resolved local feedback signals to coordinate their decision to divide in adult zebrafish brains.

[Stem Cell Research & Therapy] Scientists provide a simple method for the storage of neural stem cells as neurospheres at ambient temperature as an alternative method to more costly and inconvenient traditional methods of cryopreservation.

[Cancer Gene Therapy] Scientists focus on the use of engineered cells to treat glioblastoma, with an emphasis on data from the small number of clinical trials that have been performed to date and the lessons learned from these.

[Signal Transduction and Targeted Therapy] Scientists summarize the basic characteristics, adaptive transition and implications of glioblastoma stem cells in glioblastoma therapy.