neurons

[Nature] Loss of TDP-43 from the nucleus in human brain, neuronal cell lines and motor neurons derived from induced pluripotent stem cells resulted in the inclusion of a cryptic exon in UNC13A mRNA and reduced UNC13A protein expression.

[Brain] Investigators reinforced the connection between aberrant cytosolic-to-endoplasmic reticulum acetyl-CoA flux and the development of an autistic-like phenotype.

[Cell Death & Differentiation] Scientists established a sequenced motor neurons (MN)-muscle co-differentiation system to engineer an in vitro functional 3D NMJ model for molecular studies and demonstrated that Cellular retinoic acid-binding protein 1 (CRABP1) in MNs contributes to NMJ formation and maintenance.

[Molecular Psychiatry] Investigators used hiPSCs along with CRISPR-Cas9 gene editing to investigate the contribution of chromosome 21 candidate genes to Alzheimer’s disease-relevant neuronal phenotypes.

[FASEB Journal] Checkpoint kinase 1 (ChK1)-mediated Cancerous Inhibitor of PP2A (CIP2A) overexpression drove inhibition of PP2A and activated STAT3, then led to reactive astrogliosis and neurodegeneration in vitro.

[Translational Stroke Research] The authors investigated the role of Mfn1-βIIPKC interaction in brain damage and neurological function in both in vivo and in vitro experimental subarachnoid hemorrhage models.