NF-κB

[Acta Pharmacologica Sinica] The authors summarize the current clinical trials with proven curative effect of colchicine in treating cardiovascular diseases.

[Journal of Interferon and Cytokine Research] Investigators showed that CCL18 did not change the expression of the inflammatory factors, interleukin (IL)-1β, IL-6, tumor necrosis factor alpha, or inducible nitric oxide synthase, but significantly induced expression of the macrophage markers, MRC-1 and ARG-1 M2, in a human microglial clone 3 cell line

[Cell Death & Disease] Scientists found that NEK2 knockdown attenuated cell proliferation, migration, invasion, and tumorigenesis of glioblastoma (GBM) while NEK2 overexpression promoted the GBM progression.

[Scientific Reports] Scientists examined the antileukemic effects of pterostilbene, a natural methylated polyphenol analog of resveratrol that is predominantly found in berries and nuts, using various human and murine leukemic cells, as well as bone marrow samples obtained from patients with leukemia.

[European Journal of Pharmacology] The authors assessed the direct anti-inflammatory effects of sodium-glucose co-transporter 2 inhibitors dapagliflozin on two cell types involved in the process of atherogenesis.

[Aging Cell] The authors screened the gene expression profiles of human bone marrow MSCs (BMSCs) from young and old donors and identified that elevation of the nucleosome assembly protein 1-like 2 (NAP1L2) expression was correlated with BMSC senescence and impaired osteogenesis.