NF-κB

[Experimental and Molecular Medicine] Scientists identified and functionally validated a lncRNA using human atherosclerotic plaques. Human aortic samples were obtained from patients who underwent aortic surgery, and tissues were classified according to atherosclerotic plaques.

[Cell Death & Disease] Scientists compared the effects of cancer-associated fibroblasts (CAFs)-derived exosomes and normal fibroblasts (NFs)-derived exosomes on breast cancer cells migration and invasion and showed that CAFs-derived exosomes had a more enhancing effect on breast cancer cells migration and invasion than NFs-derived exosomes.

[Experimental & Molecular Medicine] Researchers identified and functionally validated a long noncoding RNAs using human atherosclerotic plaques. Human aortic samples were obtained from patients who underwent aortic surgery, and tissues were classified according to atherosclerotic plaques.

[Signal Transduction and Targeted Therapy] The authors showed that natural killer (NK)-derived exosomes from lean mice attenuated obesity-induced insulin resistance and inflammation in mice of type 2 diabetes, and that lean NK-derived exosomes enhanced insulin sensitivity and relieve inflammation in adipocytes and hepatocytes.

[Experimental and Molecular Medicine] The authors review the biochemical steps of hepatic lipid metabolism, dysregulated lipid metabolism in obesity and nonalcoholic fatty liver disease (NAFLD), and the roles of IκB kinase complexes and TANK-binding kinase 1 in obesity and NAFLD.

[iScience] Investigators utilized the biotin ligase -TurboID fusion with Toxoplasma gondii surface antigen 1 (TgSAG1) to identify the host proteins interacting with TgSAG1, and identified that S100A6 was co-localized with TgSAG1 when T. gondii attached to the host cell.