NF-κB

[Science Advances] Scientists found a remarkable activation of type I interferon (IFN-I) signaling in whole blood, peripheral blood mononuclear cells, monocytes, and serum from patients with OTULIN deficiency.

[Cancer Science] The authors investigated the anti-adult T cell leukemia/lymphoma effects of a novel oral HSP90 inhibitor TAS-116 and the mechanisms involved in ex vivo and in vivo preclinical models.

[iScience] Scientists showed that Drosophila NF-κB signaling was activated via a pathway in parallel with the Toll receptor by receptor-type guanylate cyclase, Gyc76C.

[Animal] To investigate the preservative effects of vascular endothelial growth factor sensitization on ceramide-mediated programmed cell death of cardiomyocytes, palmitate-induced injury in H9c2 cells was established as an in vitro model.

[Cancer Research] Emerging evidence indicates B cell activating factor (BAFF) to be an important cytokine for anti-tumor immunity. The authors generated a BAFF-overexpressing B16.F10 melanoma cell model and found that BAFF-expressing tumors grew more slowly in vivo than control tumors.

[Journal of Biological Chemistry] Scientists examined for the first time the effect of N-myc-downregulated gene 1 (NDRG1) on androgen receptor expression, activation, and downstream signaling in LNCaP, 22Rv1 and C4-2B prostate cancer cell types.