obesity

[Scientific Reports] Scientists showed that mice haploinsufficient for MDM2, a key regulator of p53, in their adipose stores suffered from overt obesity, glucose intolerance, and hepatic steatosis.

[Biochimie] Semaglutide increased islet cell proliferation and recovered islet size and alpha- and beta-cell masses.

[Reviews in Endocrine & Metabolic Disorders] The authors summarize some of the knowledge regarding the presence of adipose tissue in particular tissues, describing the composition of its adipogenic precursors, and the interactions responsible for the development of organ pathologies.

[Scientific Reports] Scientists developed an in vitro model of adipose tissue to study adipocyte-fibroblast crosstalk in a hypoxic environment. The model was used to investigate the effect of hypoxia on adipocyte mechanical properties via ras homolog gene family member A (RhoA)/Rho-associated coiled-coil kinases signaling pathways.

[Frontiers in Physiology] The author considers the impact of metabolic disorders, such as obesity and type 2 diabetes, on the regulation of [Ca2+]i in skeletal muscle.

[Nature] Scientists showed that dietary fructose improved the survival of intestinal cells and increased intestinal villus length in several mouse models.