obesity

[iScience] Although contributing to diet-induced obesity and fatty liver, Suppressors of Cytokine Signaling 3 (SOCS3) was nevertheless critical to suppress excess myeloid hematopoiesis and severe systemic inflammation associated with intestinal dysbiosis on a high-fat diet.

[Nature Reviews Endocrinology] Scientists summarize the role of autophagy in the pathogenesis of metabolic diseases associated with or occurring in the context of aging, including insulin resistance, type 2 diabetes mellitus and sarcopenic obesity, and describes its potential as a therapeutic target.

[Cell Metabolism] Levels of eIF5AHyp were found to be increased in adipose tissue macrophages from obese mice and in murine macrophages activated to a proinflammatory M1-like state.

[Nature Metabolism] FA2H was a direct target of miR-3075 and small interfering RNA depletion of FA2H in adipocytes, myocytes and primary hepatocytes led to increased insulin sensitivity. In chronic obesity, hepatocyte exosomes promoted a state of insulin resistance.

[Genome Medicine] Human induced pluripotent stem-derived skeletal muscle cells from a healthy donor and Becker Muscular Dystrophy patients were utilized to study dystrophin in muscular dystrophy post-translational modifications and associated proteins.

[Scientific Reports] Scientists analyzed the effect of obesity on advanced glycation endproducts (AGEs) accumulation, AGE-receptors and AGE-detoxification, and whether the absence of RAGE may have improved hepatosteatosis and inflammation, by comparing the liver of lean control, obese and obese RAGE-deficient mice.