Deletion of RAGE Fails to Prevent Hepatosteatosis in Obese Mice Due to Impairment of Other AGEs Receptors and Detoxifying Systems

Scientists analyzed the effect of obesity on advanced glycation endproducts (AGEs) accumulation, AGE-receptors and AGE-detoxification, and whether the absence of RAGE may have improved hepatosteatosis and inflammation, by comparing the liver of lean control, obese and obese RAGE-deficient mice.