organoids

[Laboratory Investigation] Investigators used a barcode labelling approach of glioma-initiating cells to generate clonal populations over a number of passages, in combination with phenotyping using the established stem cell markers CD133, CD15, CD44, and A2B5.

[Molecular Psychiatry] Scientists utilized patient-derived iPSCs to generate 3D cerebral organoids to model neuropathology of schizophrenia during its early-arising neurodevelopmental period.

[Nature Communications] Scientists generated gastric organoids from fetal, pediatric, and adult biopsies as in vitro models of SARS-CoV-2 infection.

[Nature Materials] Investigators reported a family of synthetic hydrogels that promoted extensive organoid morphogenesis through dynamic rearrangements mediated by reversible hydrogen bonding.

[JCI Insight] Scientists combined SARS-CoV-2 variants with genome edited kidney organoids and clinical data to investigate tropism, mechanism, and therapeutics.

[Cell] Scientists review recent progress on uncovering the cellular and molecular principles of human brain organogenesis in vivo as well as using organoids and assembloids in vitro to model features of human evolution and disease.