organoids

[Annual Review of Medicine] Organoid models recapitulate many characteristics of in vivo disease and are providing new insights into human respiratory, gastrointestinal, and neuronal host-microbe interactions.

[American Journal of Physiology-Gastrointestinal and Liver Physiology] Organoid-derived intestinal co-culture models have established themselves as convenient tools to re-enact such pathophysiological events, explore interactions between selected cell populations and assess their roles with a central focus on intestinal barrier recovery and stabilization.

[Nature Communications] Scientists showed a role of guidance receptor Plexin-B2 in organizing actomyosin network and adhesion complexes during multicellular development of human embryonic stem cells and neuroprogenitor cells.

[Oncogene] To identify genetic vulnerabilities of colon cancer, investigators performed targeted CRISPR dropout screens comprising 657 Drugbank targets and 317 epigenetic regulators on two patient-derived colon cancer stem cells-enriched spheroids.

[Nature Physics] Investigators demonstrated that epithelial gland morphogenesis was induced by a local change from anisotropic to isotropic tension within the epithelial cell layer of developing human mammary gland organoids.

[Physiological Genomics] Investigators explored the effect on the transcriptome of common variations in culture methods, including extracellular matrix substrate, format, tissue segment, differentiation status, and patient heterogeneity.