organoids

[Mammalian Genome] Scientists review existing strategies for fabricating and incorporating vascular elements and perfusion within tissue organoids.

[Microsystems & Nanoengineering] The authors developed a tumor-chip device engineered to mimic the pancreatic ductal adenocarcinoma tumor microenvironment by incorporating patient-derived organoids and stromal cells, specifically pancreatic stellate cells and macrophages.

[Science Translational Medicine] In response to PX-478 treatment, human islet organoids chronically exposed to high glucose presented improved stimulation index of glucose-induced insulin secretion.

[Biomaterials] Tthe culture and expansion of human cholangiocyte organoids in liver extracellular matrix-derived hydrogels is described. These hydrogels supported proliferation of cholangiocyte organoids and maintain the cholangiocyte-like phenotype.

[Vyant Bio, Inc.] Vyant Bio, Inc. and OrganoTherapeutics announced they have entered into a collaboration agreement to work toward accelerating the discovery of drugs for the treatment of Parkinson’s Disease.

[Nature Communications] Researchers demonstrated that gastrointestinal tissue-derived ECM hydrogels were suitable substitutes for Matrigel in gastrointestinal organoid culture.