organoids

[Scientific Reports] The authors described an analysis of nearly 3500 individual mouse-derived cancer organoids where individual organoid morphologic tracking was performed.

[Cell Death & Differentiation] The authors showed that fatty acids activate Drp1 to promote metabolic plasticity in cancer cells. Uptake of fatty acids induced mitochondrial fragmentation by promoting ERK-dependent phosphorylation of Drp1 at the S616 site.

[Science Advances] Scientists used a transcriptomics-guided drug target discovery strategy using gene signatures of smoking-associated COPD and from mice chronically exposed to cigarette smoke, identifying druggable targets expressed in alveolar epithelial progenitors, of which they screened the function in lung organoids.

[Nature Biomedical Engineering] Researchers showed that patterned organoids and bioprinted tissues with controlled composition and organization could be generated by simultaneously co-differentiating hiPSCs into distinct cell types via the forced overexpression of transcription factors, independently of culture-media composition.

[Advanced Science] Investigators developed in vitro methods using a kidney decellularized ECM hydrogel to culture human pluripotent stem cell-derived kidney organoids, which had extensive vascular network and their own endothelial cells.

[Advanced Science] The assembly of self-organizing 3D kidney-like structures was observed. Kidney organoids contain podocytes, proximal tubules, and endothelial cells that form networks of capillary loop-like structures.