organoids

[Oncogene] Researchers showed that cytoplasmic complexes composed of steroid receptor co-activators, PELP1 and SRC-3, modulated breast cancer stem cell expansion through upregulation of the HIF-activated metabolic target genes PFKFB3 and PFKFB4.

[iScience] Scientists showed that a sub-population of cells in a human iPSC-derived corneal epithelial cell sheet is positive for ATP-binding cassette, sub-family B, member 5, a functional marker of adult corneal epithelial stem cells.

[Clinical Cancer Research] Researchers examined the ability of patient-derived organoids to predict clinical responses to targeted therapies in individual patients and to identify effective anti-cancer therapies for novel molecular targets.

[Nature] Researchers investigated how Apc-mutant cells gain a clonal advantage over wild-type counterparts to achieve fixation and found that Apc-mutant cells were enriched for transcripts that encoded several secreted WNT antagonists, with Notum being the most highly expressed.

[Current Opinion in Genetics & Development] The authors review recent advances within intestinal regenerative biology and the emerging concept of fetal-like reprogramming, in which the adult intestinal epithelium transiently enters a repair-associated state reminiscent of ontologically pre-existing stages.

[Micromachines] Investigators described a novel in situ cryopreservation technology on the superhydrophobic microwell array chip-chip to preserve the viability of the organoids for future drug sensitivity tests.