p16

[Laboratory Investigation] The proportion of Th17 cells in the spleen and the expression levels of IL-17A, IL-6, and vascular cell adhesion molecule- in mice of different ages were increased with aging.

[Scientific Reports] Investigators studied whether and to what extent the conditionally immortalized cell line hFOB 1.19 could serve as a surrogate model for bone-marrow derived MSCs.

[Developmental Cell] The authors uncovered a dual role for Rank in the mammary epithelia: Rank induced senescence and stemness, delaying tumor initiation but increasing tumor aggressiveness.

[Bioconjugate Chemistry] P16-093 was labeled with 18F via [18F]AlF2+ complex formation, and the biological properties of [18F]AlF-P16-093 were evaluated. In vitro, [18F]AlF-P16-093 showed prostate-specific membrane antigen (PSMA)-specific high uptakes in PIP-PC3 cells.

[Experimental and Molecular Medicine] Inhibition of senescence-induced upregulation of hypoxia-inducible factor-2α expression during matrix maturation, but not during the proliferation stage of osteoblast differentiation, reversed the age-related decrease in Runx2 and Ocn expression.

[Oncogene] Scientists demonstrated that the histone variant H2A.Z was highly expressed in PDAC cell lines and PDAC patients and that its overexpression correlated with poor prognosis.