Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell NewsThe proportion of Th17 cells in the spleen and the expression levels of IL-17A, IL-6, and vascular cell adhesion molecule- in mice of different ages were increased with aging.
[Laboratory Investigation]
6445212 C8545CH5 items 1 apa 0 default asc 1 163978 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-cb88d9a1fb425d39a7ceb1cf8228bd6d%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22C8545CH5%22%2C%22library%22%3A%7B%22id%22%3A6445212%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Zhang%20et%20al.%22%2C%22parsedDate%22%3A%222021-06-25%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EZhang%2C%20L.%2C%20Liu%2C%20M.%2C%20Liu%2C%20W.%2C%20Hu%2C%20C.%2C%20Li%2C%20H.%2C%20Deng%2C%20J.%2C%20Cao%2C%20Q.%2C%20Wang%2C%20Y.%2C%20Hu%2C%20W.%2C%20%26amp%3B%20Li%2C%20Q.%20%282021%29.%20Th17%5C%2FIL-17%20induces%20endothelial%20cell%20senescence%20via%20activation%20of%20NF-%26%23x3BA%3BB%5C%2Fp53%5C%2FRb%20signaling%20pathway.%20%3Ci%3ELaboratory%20Investigation%3C%5C%2Fi%3E%2C%201%26%23x2013%3B9.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41374-021-00629-y%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41374-021-00629-y%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445212%26amp%3Bitem_key%3DC8545CH5%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Th17%5C%2FIL-17%20induces%20endothelial%20cell%20senescence%20via%20activation%20of%20NF-%5Cu03baB%5C%2Fp53%5C%2FRb%20signaling%20pathway%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Liang%22%2C%22lastName%22%3A%22Zhang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Manli%22%2C%22lastName%22%3A%22Liu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wenhua%22%2C%22lastName%22%3A%22Liu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Chaojie%22%2C%22lastName%22%3A%22Hu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Hongqi%22%2C%22lastName%22%3A%22Li%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Jie%22%2C%22lastName%22%3A%22Deng%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Qi%22%2C%22lastName%22%3A%22Cao%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yiping%22%2C%22lastName%22%3A%22Wang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Wei%22%2C%22lastName%22%3A%22Hu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Qing%22%2C%22lastName%22%3A%22Li%22%7D%5D%2C%22abstractNote%22%3A%22Cellular%20senescence%20is%20a%20key%20mechanism%20of%20age-related%20vascular%20endothelial%20dysfunction.%20Interleukin-17A%20%28IL-17A%29%20is%20an%20inflammatory%20cytokine%20produced%20by%20Th17%20cells%20%28a%20subgroup%20of%20helper%20T%20cells%29%2C%20which%20is%20a%20key%20factor%20in%20the%20development%20of%20atherosclerosis.%20However%2C%20the%20effect%20of%20IL-17A%20on%20the%20senescence%20of%20vascular%20endothelial%20cells%20is%20still%20unclear.%20In%20this%20study%2C%20we%20aimed%20to%20explore%20the%20role%20of%20IL-17A%20on%20endothelial%20cell%20senescence%20and%20its%20signaling%20pathways%20associated%20with%20senescence.%20The%20proportion%20of%20Th17%20cells%20in%20the%20spleen%20and%20the%20expression%20levels%20of%20IL-17A%2C%20IL-6%2C%20and%20vascular%20cell%20adhesion%20molecule-1%20%28VCAM-1%29%20in%20mice%20of%20different%20ages%20were%20increased%20with%20aging.%20In%20vitro%20experiments%20showed%20that%20proliferation%20was%20inhibited%2C%20senescent%20%5Cu03b2-galactosidase%20and%20senescence-associated%20proteins%20%28p16%2C%20p19%2C%20p21%2C%20and%20p53%29%20of%20mouse%20aortic%20endothelial%20cells%20%28MAECs%29%20were%20increased%20with%20IL-17A%20treatment.%20Blocking%20the%20NF-%5Cu03baB%20pathway%20with%20ammonium%20pyrrolidinedithiocarbamate%20%28PDTC%29%20successfully%20inhibited%20IL-17A-induced%20expression%20of%20senescence-associated%20proteins.%20In%20conclusion%2C%20our%20data%20reveal%20a%20previously%20unsuspected%20link%20between%20IL-17A%20and%20endothelial%20cell%20senescence%2C%20which%20was%20mediated%20by%20the%20NF-%5Cu03baB%20%5C%2Fp53%5C%2FRb%20pathway.%22%2C%22date%22%3A%222021-06-25%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41374-021-00629-y%22%2C%22ISSN%22%3A%221530-0307%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41374-021-00629-y%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-06-25T16%3A19%3A19Z%22%7D%7D%5D%7D
Zhang, L., Liu, M., Liu, W., Hu, C., Li, H., Deng, J., Cao, Q., Wang, Y., Hu, W., & Li, Q. (2021). Th17/IL-17 induces endothelial cell senescence via activation of NF-κB/p53/Rb signaling pathway. Laboratory Investigation, 1–9. https://doi.org/10.1038/s41374-021-00629-y Cite
