p21

[Cell Death Discovery] The authors demonstrated that MMP1 derived from tumor-associated macrophages markedly facilitated colon cancer cell proliferation via accelerating cell cycle transition from G0/G1 to S and G2/M phase.

[Nature Cell Biology] Scientists showed that Ddx21 was enriched in sprouting venous endothelial cells in response to Vegfc–Flt4 signalling. Ddx21 function was essential for Vegfc–Flt4-driven endothelial cell proliferation.

[Proceedings of the National Academy of Sciences of the United States of America] Scientists studied the dynamical expression of endogenously labeled Hes1, a transcriptional repressor implicated in controlling cell proliferation, to understand how cell-cycle length heterogeneity was generated in estrogen receptor (ER)+ breast cancer cells.

[International Journal of Cardiology] Researchers revealed that programmed cell death 5 (Pdcd5) deficiency attenuated cardiac aging by reducing cellular senescence and apoptosis, and increasing Parkin-mediated mitophagy, likely through p53.

[Cell Death Discovery] Investigators found that proteasome 26 S subunit ATPase 2 (PSMC2) was significantly upregulated in skin cutaneous melanoma (SKCM) patients from The Cancer Genome Atlas datasets and verified in clinical SKCM tissues.

[Science] To better understand the molecular properties of senescent cells (SNCs), researchers identified key determinants of SNC identity by screening for genes nearby senescence-associated super-enhancers conserved across stressors, cell types, and mammalian species.