p21

[Leukemia] The authors review the most recent studies that provide experimental evidence showing how specific p21-activated kinases regulate the properties of leukemic stem cells and drug-resistant cells to initiate and maintain hematological malignancies.

[Science Translational Medicine] Lung autopsy samples from 18 patients with fatal COVID-19, with symptom onset-to-death times ranging from 3 to 47 days, and antemortem plasma samples from 6 of these cases were evaluated using deep sequencing of SARS-CoV-2 RNA, multiplex plasma protein measurements, and pulmonary gene expression and imaging analyses.

[BMC Cancer] Investigators conducted microarray gene expression analysis and compared FX-9 exposed and unexposed prostate cancer cells, followed by pathway analysis and gene annotation to functional processes.

[Oncogene] The authors observed coordinate expression of IER2, p53/p21, and osteopontin in primary human melanomas and metastases, which highlighted the pathophysiological relevance of IER2-mediated senescence in melanoma progression.

[Pharmacological Research] The authors showed that the number of endothelial progenitor cells (EPCs) in hypertensive patients was significantly lower than that of normal population, and the cell function decreased with a higher proportion of EPCs at later stages.

[Communications Biology] The authors demonstrated that TC10, a member of a Cdc42 subfamily of p21 small GTPases, regulated the membrane type 1 matrix metalloproteinase-driven extracellular matrix degradation at invadopodia.