p53

[Nature Cell Biology] Scientists showed that Ddx21 was enriched in sprouting venous endothelial cells in response to Vegfc–Flt4 signalling. Ddx21 function was essential for Vegfc–Flt4-driven endothelial cell proliferation.

[Molecular Cancer therapeutics] Scientists suggested that DNA methylation pathway is deregulated after enzalutamide resistance onset and that targeting DNA methyltransferases restored the sensitivity to enzalutamide in prostate cancer cells.

[Oncology Reports] The combined effect of Diosmin and naringenin in colon cancer cell lines HCT116 and SW480 were assessed by targeting apoptosis and inflammatory pathways.

[Clinical Cancer Research] Investigators showed that DNMT3A mutations underlied a defect in recovery from replication fork arrest with subsequent accumulation of unresolved DNA damage, which may have therapeutic tractability.

[Cell Death Discovery] The authors investigated the effects of wild-type p53-induce phosphatase 1 (Wip1) on regulating MSCs immunosuppressive capacities in type 1 diabetes mellitus mice.

[Stem Cell Reports] Wdr5 deletion in p53-null mouse ESCs led to impaired self-renewal, defective retinal neuroectoderm differentiation, and de-repression of germ cell/meiosis-specific genes.