p53 Inactivation Unmasks Histone Methylation-Independent WDR5 Functions That Drive Self-Renewal and Differentiation of Pluripotent Stem Cells

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Wdr5 deletion in p53-null mouse ESCs led to impaired self-renewal, defective retinal neuroectoderm differentiation, and de-repression of germ cell/meiosis-specific genes.
[Stem Cell Reports]
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