p53

[Journal of Pathology Clinical Research] The authors investigated the expression of two PD-1 ligands, PD-L1 and PD-L2, in pancreatic ductal adenocarcinoma, analysed their role in survival, and explored their correlation with clinicopathological features, immune infiltration, and DNA damage response molecules.

[Cell Death Discovery] By establishing a mouse model of radiation-induced lung injury and orthotopic lung tumor-bearing mouse model, investigators detected the role of Rac1 inhibition in the protection of RILI and suppression of lung tumor.

[Bioorganic Chemistry] Caffeine has been studied as a potentiating agent in chemotherapy against some types of cancer, but there are few reports on its effects on melanoma. Scientists investigated caffeine's ability to enhance the effects of dacarbazine in vitro.

[Cell Biology International] HPV16 E6 silence or overexpression were carried out to evaluate the possible mechanisms of HPV16 E6 function in cervical cancer cells with different HPV16 E6 expression background.

[Cell Death & Differentiation] Researchers demonstrated that a novel Olig2-binding protein, DEAD-box helicase 20 (Ddx20), was indispensable for the survival of neural progenitor cells and oligodendrocyte progenitor cells.

[Stem Cells International] Scientists discovered that p57Kip2 (p57), a cyclin-dependent kinase inhibitor canonically inhibiting cell proliferation, played a role in suppressing the pluripotency state of mouse ESCs.