p53

[International Journal of Oral Science] Scientists identified a molecular mechanism in iPSCs responding to intermittent compressive force by analyzing the global gene expression profile.

[Clinical Cancer Research] Scientists investigated the recommended dose for expansion of siremadlin, a p53-MDM2 inhibitor, in patients with wild-type TP53 advanced solid or hematologic cancers.

[Cell Cycle] Knockout of killin in human colorectal cells led to a dramatic decrease in p53-mediated G1 arrest upon DNA damage.

[Journal of Cellular and Molecular Medicine] Researchers developed a 6-gene immune-related risk model to predict the survival of patients with lung adenocarcinoma (LUAD) in The Cancer Genome Atlas cohort based on TP53 status, and the predictive ability was confirmed in two independent cohorts.

[Biochimica et Biophysica Acta-Reviews On Cancer] Scientists describe the involvement of p53 signaling reactivation in pancreatic cancer (PC) treatment as well as its underlying molecular mechanisms, thereby providing useful insights for targeting p53-related signal pathways in PC therapy.

[Molecular Biology Reports] Researchers reported that berberine has important antiproliferative effects and may be alone or in adjunct therapy a promising candidate for melanoma treatment, a cancer with great incidence and high lethality.