pAkt

[Scientific Reports] Silencing HNF1α reduced the proliferative, migratory, invasive and colony forming capabilities of pancreatic cancer cells.

[Cell Reports Medicine] Using several human and mouse models of PDACs, scientists demonstrated rapid acquisition of tumor resistance in response to targeting KRAS or MEK, associated with integrin-linked kinase-mediated increased phosphorylation of the mTORC2 component Rictor, and AKT.

[FASEB Journal] The authors showed that melanocyte survival was mediated by diverse, nonredundant signaling pathways, including ERK1/2, AKT, PKA, and PKC.

[Cell Death & Disease] Scientists report that impaired autophagy participated in sonic hedgehog signaling pathway-induced endometrial fibrosis.

[Molecular Biology Reports] Scientists investigated the effect of cellular retinol binding protein-1 (CRBP-1) transfection in the H460 human non-small cell lung cancer cell line, normally not expressing CRBP-1.

[Life Sciences] pigallocatechin-3-gallate (EGCG) induced an internal Ca2+ increase in prostate cancer (PCa) cells by a multi-step mechanism. Researchers confirmed the possibility of using EGCG as a synergistic adjuvant in combined therapies for recalcitrant malignancies like androgen-independent PCa.