pancreatic cancer

[Molecular & Cellular Proteomics] Researchers observed both common and distinct patterns of glycosylation in pancreatic cancer across species. Common alterations included increased levels of α-2,3- and α-2,6-sialic acids, bisecting GlcNAc and poly-LacNAc.

[Cancer Science] Scientists showed that the suppression of SNAIL2 expression using RNA interference decreased tumorigenicity in vitro and in vivo in two pancreatic cancer cell lines, KLM1 and KMP5.

[Oncology Reports] Researchers focused upon the effect of propofol on pancreatic cancer cells and the mechanism by which propofol reduced A disintegrin and metalloproteinase 8 (ADAM8) expression.

[Molecular Medicine Reports] RO 48‑8071 (RO) was used to treat the pancreatic cancer cell line in vitro to examine the effects of RO on cell viability, as well as to determine its potential molecular mechanism.

[Acta Biochimica Et Biophysica Sinica] SETD8 mediated receptor tyrosine kinase-like orphan receptor 1 (ROR1) activity and regulated pancreatic cancer cells invasion and migration, although promoting the expression of stemness and epithelial–mesenchymal transition-related molecules.

[American Journal of Human Genetics] Scientists proposed that intracellular accumulation of a nonfunctional chymotrypsinogen B2 protein led to endoplasmic reticulum stress and pancreatic inflammation, which might explain the increased pancreatic cancer risk in carriers of CTRB2 exon 6 deletion alleles.