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protein expression

m6A Demethylase ALKBH5 Controls CD4+ T Cell Pathogenicity and Promotes Autoimmunity

[Science Advances] Investigators reported that m6A eraser AlkB homolog 5, but not FTO, maintained the ability of naïve CD4+ T cells to induce adoptive transfer colitis.

TMSB10 Can Serve as a Potential Prognosis Prediction Biomarker and Promotes the Invasion and Angiogenesis of Gastric Cancer

[Journal of Gastroenterology and Hepatology] The thymosin beta 10's roles and potential mechanisms in regulating tumor growth, invasion and angiogenesis were evaluated by TMSB10 knockdown/overexpression of gastric cancer cells in vitro and ex vivo.

High Fluid Shear Stress Prevents Atherosclerotic Plaque Formation by Promoting Endothelium Denudation and Synthetic Phenotype of Vascular Smooth Muscle Cells

[Molecular Medicine Reports] The authors investigated the role of high shear stress (HSS) in atherosclerotic plaque formation. In vitro modeling used human umbilical vein endothelial cells and vascular smooth muscle cells exposed to HSS using a parallel‑plate flow system.

Enhanced Efficiency of Nonviral Direct Neuronal Reprogramming on Topographical Patterns

[Biomaterials Science] The authors used a polymer-BAM (Brn2, Ascl1, Myt1l) factor transfection polypex to reprogram primary mouse embryonic fibroblasts. Using a multiarchitecture chip, they screened for patterns that may improve transfection and/or subsequent induced neuron reprogramming efficiency.

Porcine Primordial Germ Cell-Like Cells Generated from Induced Pluripotent Stem Cells under Different Culture Conditions

[Stem Cell Reviews and Reports] The authors analyzed the influence of the in vitro environment on the induction of porcine iPSCs differentiation into primordial germ cell-like cells, providing a suitable in vitro model for use in translational studies and to help answer numerous remaining questions about germ cells.

Mesenchymal Stromal (Stem) Cell (MSC) Therapy Modulates miR-193b-5p Expression to Attenuate Sepsis-Induced Acute Lung Injury

[European Respiratory Journal] The authors showed that treatment with MSCs decreased expression of host-derived miR-193b-5p and increased expression of its target gene, the tight junctional protein occludin, in lungs from septic mice.

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