pulmonary cells

[Cell Reports] Through in vivo lineage tracing and in vitro molecular experiments, scientists revealed that reduced YAP/TAZ activity promoted intrinsic goblet transdifferentiation of secretory airway epithelial cells.

[BMC Immunology] Scientists examined the expression of NKG2DLs, PD-L1 and PD-L2 in lung cancer cells after treatment of TGF-β and a TGF-β inhibitor, Galunisertib.

[Scientific Reports] Researchers found that Stathmin (STMN1) was overexpressed in lung cancer tissues and associated with worse survival rates of lung cancer patients.

[Proceedings of the National Academy of Sciences of the United States of America] The authors demonstrated that interdomain communication through small RNA–containing membrane vesicles was bidirectional and that miRNAs in extracellular vesicles secreted by human airway epithelial cells regulated protein expression, antibiotic sensitivity, and biofilm formation by P. aeruginosa.

[Signal Transduction and Targeted Therapy] Scientists identified the role and mechanism of AFAP1-AS1 in lung cancer. The AFAP1-AS1 expression was firstly assessed in 187 paraffin-embedded lung cancer and 36 normal lung epithelial tissues by in situ hybridization.

[Laboratory Investigation] In vitro, epithelial-mesenchymal transition (EMT) was induced by the administration of transforming growth factor-β1 in a human alveolar epithelial cell line.