pulmonary cells

[Genes and Environment] Researchers quantitatively measured the methylation content of Alu and LINE1 in particulate matter-treated normal human bronchial epithelial cells and normal human epidermal keratinocytes by using whole-genome bisulfite sequencing and pyrosequencing.

[Nature Communications] The authors reported that PF-332 exerted equipotent in vitro activity against the four SARS-CoV-2 variants of concerns and that it could completely arrest replication of the alpha variant in primary human airway epithelial cells grown at the air-liquid interface.

[Archiv Der Pharmazie] Scientists provided novel androgen receptor (AR)-directed proteolysis-targeting chimeras (PROTACs) and a clear rationale for further investigating AR involvement in lung cancer models.

[American Journal of Physiology-Lung Cellular and Molecular Physiology] The authors demonstrated that antibody-induced leukemia inhibitory factor (LIF) blockade remodeled the lung epithelial transcriptome in association with increased apoptosis.

[Oncotarget] The researchers' analysis of The Cancer Genome Atlas (TCGA) expression data revealed that p50-associated COX-2 extragenic RNA (PACER) expression was significantly higher in lung adenocarcinomas than normal lung tissues.

[Cell Death Discovery] Researchers used a library containing approved drugs to screen for drugs that preferentially reduce cell viability in lung fibroblasts from an IPF patient compared with a human alveolar epithelial cell line.