pulmonary cells

[Journal of Experimental & Clinical Cancer Research] The authors reported that stimuli from the embryonic lung could modulate the malignant phenotype of lung cancer cells, control their growth capacity and activate their differentiation into myofibroblasts.

[Nature Communications] The authors analyzed single-cell RNA sequencing profiles of explanted lung tissue from subjects with advanced COPD or control lungs and identified a subpopulation of alveolar epithelial type II cells with transcriptional evidence for aberrant cellular metabolism and reduced cellular stress tolerance in COPD.

[American Journal of Physiology-Lung Cellular and Molecular Physiology] Investigators presented a human iPSC-derived airway epithelial platform, composed of the major airway epithelial cell types, that was permissive to SARS-CoV-2 infection.

[iScience] Researchers used de-identified human remnant transplant lungs to develop a method to establish alveolar epithelial cell lines. The lines grew well in 2D culture as epithelial monolayers expressing lung progenitor markers.

[Journal of Clinical Investigation] Using androgen receptor (AR) deficient and Foxp3 fate-mapping mice, researchers determined that AR signaling increased Treg suppression during Alternaria extract challenge by stabilizing Foxp3+ Tregs and limiting the number of ST2+ ex-Tregs and IL-13+ Th2 and ex-Tregs.

[Journal of Immunology] Using a mouse model of sepsis, scientists found that the long noncoding RNA HOXA transcript antisense RNA myeloid-specific 1 (HOTAIRM1) was highly expressed in mice during the late phase of sepsis.