regulatory T cells

[Cell Death & Disease] Investigators found that interference with GPR120 activity using pharmacological agonist attenuated the severity of the liver injury and mortality of fulminant hepatic failure in mice.

[International Journal of Oral Science] Investigators showed that compared with MSC-exosomes (exos) generated via 2D culture, 3D-exos showed enhanced anti-inflammatory effects in a ligature-induced model of periodontitis by restoring the reactive T helper 17 cell/Treg balance in inflamed periodontal tissues.

[Nature Communications] The authors showed that despite a significant reduction in peripheral effector Treg cells, clinical responses are minimal in a cohort of patients with advanced CCR4-negative solid cancer in a Phase Ib study.

[Scientific Reports] Scientists performed fully-mismatched heart transplantations and found combination treatment to result in prolonged allograft survival.

[PLoS Pathogens] Investigators examined the effect of transient breakdown of the immunological tolerance induced by Treg-cell depletion on adaptive immune responses against administered SARS-CoV-2 antigen, spike protein 1.

[Science] Unconventional T cells compete for niches within tissues, and recent evidence supports the idea that the fundamental role of these cells in tissue physiology may result from their action as a network with overlapping and potentially synergistic functions, rather than as individual subsets.