regulatory T cells

[Drug Delivery and Translational Research] Scientists used poly (lactic-co-glycolide) to co-encapsulate type 1 diabetes-relevant antigen and 3 distinct TREG-inducing molecules - rapamycin, all-trans retinoic acid, and butyrate - that targeted the mechanistic target of Rapa, the retinoid pathway, and histone deacetylase inhibition, respectively.

[Nature Immunology] Scientists characterized the immunology of neonates born to mothers with confirmed SARS-CoV-2 infection during pregnancy. They showed that maternal SARS-CoV-2 infection affected the neonatal immune system.

[Surface Oncology] Surface Oncology, an immuno-oncology company developing next-generation immunotherapies that target the tumor microenvironment, announced details about its plan to initiate a randomized Phase II clinical study evaluating SRF388, in combination with Roche’s atezolizumab and bevacizumab, in patients with treatment-naïve hepatocellular carcinoma.

[Nature Communications] Using single-cell RNA sequencing of immune cells from renal clear cell carcinoma patients, investigators identified two distinct transcriptional fates for tumor-infiltrating Treg cells, Fate-1 and Fate-2.

[European Journal of Cancer] Murine breast cancer cells were grown in both immune-competent and -deficient BALB/c mice, and tumors were irradiated by three fractions of 24 Gy. A PD-1 blockade and a phosphoinositide 3-kinase (PI3K)γδ inhibitor were then administered every other day for two weeks.

[Mucosal Immunology] T cells located in non-lymphoid tissues have come to prominence in recent years. CD8+ tissue-resident memory cells are important for tissue immune surveillance, provide an important line of defence against invading pathogens and show promise in cancer therapies.