Biomaterial-Enabled Induction of Pancreatic-Specific Regulatory T Cells through Distinct Signal Transduction Pathways

Scientists used poly (lactic-co-glycolide) to co-encapsulate type 1 diabetes-relevant antigen and 3 distinct TREG-inducing molecules – rapamycin, all-trans retinoic acid, and butyrate – that targeted the mechanistic target of Rapa, the retinoid pathway, and histone deacetylase inhibition, respectively.