regulatory T cells

[Cell Metabolism] Researchers exploited the power of a visceral adipose tissue (VAT)-Treg TCR-transgenic mouse model to follow the dynamics of, and phenotypic changes in, the VAT-Treg population throughout the development of diet-induced obesity.

[Journal of Pathology] The authors characterized and assessed the prognostic potential of distinct immune cell infiltration patterns in the prostate tumor microenvironment.

[LAVA Therapeutics, N.V.] LAVA Therapeutics N.V. announced dosing of the first patient in the company’s Phase I/IIa clinical trial of LAVA-051 in patients with relapsed and/or refractory chronic lymphocytic leukemia, multiple myeloma and acute myeloid leukemia.

[Cell Reports] Researchers showed that serine/arginine-rich splicing factor 1, which was decreased in T cells from patients with systemic lupus erythematosus, was necessary for the homeostasis and proper function of Treg cells.

[Nature Reviews Rheumatology] Some patients do not respond to TNF inhibitor treatment and rare occurrences of paradoxical disease exacerbation have been reported. These limitations on the clinical efficacy of TNF inhibitors can be explained by the differences between TNF receptor 1 (TNFR1) and TNFR2 signalling and by the diverse effects of TNF on multiple immune cells, including FOXP3+ regulatory T cells.

[Nature Communications] Scientists revealed that the transcriptional dynamics of circulating tumor cells were associated with stress response, cell cycle and immune-evasion signaling during hematogeneous transportation.