reporter assay

[Journal of Translational Medicine] The expression of miR-3065-3p in colorectal cancer and the association of miR-3065-3p expression with prognosis of patients with colorectal cancer were analyzed using TCGA dataset or clinical cases.

[Molecular Medicine] TRIM14 promoted the proliferation of acute myeloid leukemia cells via activating PI3K/AKT pathway, which was reversed by human MSC-derived exosomes through delivering miR-23b-5p.

[Molecular Medicine Reports] The authors investigated the molecular mech­­anisms of long non‑coding RNA small nucleolar RNA host gene 16 in the proliferation and metastasis of prostate cancer cells.

[Kaohsiung Journal of Medical Sciences] Scientists found that lncRNA XIST was related to the abnormal proliferation and migration of human vascular smooth muscle cells (HVSMCs), and thus, the mechanism by which XIST regulated HVSMCs was further investigated.

[Scientific Reports] Scientists demonstrated that short-term exposure to BMP7 decreased the fibrocartilage chondrocyte phenotype. The BMP7-dependent reduction of Collagen type I protein expression seemed MMP2-dependent and inhibition of Smad2/3-PAI1 activity was identified as a potential pathway via which BMP7 exerted its anti-fibrotic action.

[Oncology Reports] Researchers analyzed the effect of curcumol on prostate cancer and identify its possible internal regulatory pathway using in vitro cell culture and in vivo tumor model experiments.