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SARS-CoV-2

Mesenchymal Stem Cell Treatment Improves Outcome of COVID-19 Patients via Multiple Immunomodulatory Mechanisms

[Cell Research] MSC infusion reduced the levels of C-reactive protein, proinflammatory cytokines, and neutrophil extracellular traps, and promoted the maintenance of SARS-CoV-2-specific antibodies.

Single-Cell Profiling of Proteins and Chromatin Accessibility Using PHAGE-ATAC

[Nature Biotechnology] Researchers developed PHAGE-Assay for Transposase-Accessible Chromatin (ATAC), a massively parallel droplet-based method that used phage displaying, engineered, camelid single-domain antibodies for simultaneous single-cell measurements of protein levels and chromatin accessibility profiles, and mitochondrial DNA-based clonal tracing.

GRAd-COV2, a Gorilla Adenovirus-Based Candidate Vaccine against COVID-19, Is Safe and Immunogenic in Younger and Older Adults

[Science Immunology] The authors described a COVID-19 vaccine based on a replication-defective gorilla adenovirus expressing the stabilized pre-fusion SARS-CoV-2 spike protein, named GRAd-COV2.

Identification of Driver Genes for Critical Forms of COVID-19 in a Deeply Phenotyped Young Patient Cohort

[Science Immunology] Investigators employed a multi-omics analysis combined with artificial intelligence in a young patient cohort where major comorbidities were excluded at the onset.

Membrane Fusion and Immune Evasion by the Spike Protein of SARS-CoV-2 Delta Variant

[Science] Investigators reported the structure, function, and antigenicity of the SARS-CoV-2 Delta variant's full-length spike trimer and those of the Gamma and Kappa variants and compared their characteristics with the G614, Alpha, and Beta variants.

Immune Memory from SARS-CoV-2 Infection in Hamsters Provides Variant-Independent Protection but Still Allows Virus Transmission

[Science Immunology] Scientists demonstrated that engagement of the innate immune system following SARS-CoV-2 infection was delayed but was followed by a pronounced adaptive response.

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