On the Road Again – Establishment and Maintenance of Stemness in the Neural Crest from Embryo to Adulthood

The neural crest (NC) is an ESC population that contributes to a greatly expanding list of derivatives ranging from neurons and glia of the peripheral nervous system, facial cartilage and bone, pigment cells of the skin to secretory cells of the endocrine system. Scientists focus on what is specifically known about establishment and maintenance of NC stemness and ultimate fate commitment mechanisms.
[Stem Cells]
Perera, S. N., & Kerosuo, L. (n.d.). On the road again – establishment and maintenance of stemness in the neural crest from embryo to adulthood. STEM CELLS, n/a(n/a). https://doi.org/10.1002/stem.3283 Cite
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11q Deletion or ALK Activity Curbs DLG2 Expression to Maintain an Undifferentiated State in Neuroblastoma

The authors identified an important role for oncogenic ALK-ERK1/2-SP1 signaling in the maintenance of undifferentiated neural crest-derived progenitors through the repression of DLG2, a candidate tumor suppressor gene in neuroblastoma.
[Cell Reports]
11q Deletion or ALK Activity Curbs DLG2 Expression to Maintain an Undifferentiated State in Neuroblastoma: Cell Reports. (n.d.). Retrieved September 23, 2020, from https://www.cell.com/cell-reports/fulltext/S2211-1247(20)31160-8 Cite
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Secretion of a Mammalian Chondroitinase ABC Aids Glial Integration at PNS/CNS Boundaries

Researchers used a lentiviral chondroitinase ABC, capable of being secreted from mammalian cells, to examine the repercussions of chondroitin sulphate proteoglycans digestion upon Schwann cell behaviour in vitro.
[Scientific Reports]
Warren, P. M., Andrews, M. R., Smith, M., Bartus, K., Bradbury, E. J., Verhaagen, J., Fawcett, J. W., & Kwok, J. C. F. (2020). Secretion of a mammalian chondroitinase ABC aids glial integration at PNS/CNS boundaries. Scientific Reports, 10(1), 11262. https://doi.org/10.1038/s41598-020-67526-0 Cite
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