The neural crest (NC) is an ESC population that contributes to a greatly expanding list of derivatives ranging from neurons and glia of the peripheral nervous system, facial cartilage and bone, pigment cells of the skin to secretory cells of the endocrine system. Scientists focus on what is specifically known about establishment and maintenance of NC stemness and ultimate fate commitment mechanisms.
Perera, S. N., & Kerosuo, L. (n.d.). On the road again – establishment and maintenance of stemness in the neural crest from embryo to adulthood. STEM CELLS, n/a(n/a). https://doi.org/10.1002/stem.3283Cite
The authors identified an important role for oncogenic ALK-ERK1/2-SP1 signaling in the maintenance of undifferentiated neural crest-derived progenitors through the repression of DLG2, a candidate tumor suppressor gene in neuroblastoma.
Researchers used a lentiviral chondroitinase ABC, capable of being secreted from mammalian cells, to examine the repercussions of chondroitin sulphate proteoglycans digestion upon Schwann cell behaviour in vitro.
Warren, P. M., Andrews, M. R., Smith, M., Bartus, K., Bradbury, E. J., Verhaagen, J., Fawcett, J. W., & Kwok, J. C. F. (2020). Secretion of a mammalian chondroitinase ABC aids glial integration at PNS/CNS boundaries. Scientific Reports, 10(1), 11262. https://doi.org/10.1038/s41598-020-67526-0Cite