schwann cell precursors

[Communications Medicine] The authors reported a series of ten COVID-19 patients with audiovestibular symptoms such as hearing loss, vestibular dysfunction and tinnitus.

[NPJ Regenerative Medicine] Gingiva-derived mesenchymal stem cells (GMSCs) under 3D-culture in soft collagen hydrogel showed significantly increased expression of a panel of genes related to development/differentiation of neural crest stem-like cells and/or Schwann cell precursor-like cells and associated with NOTCH3 signaling pathway activation as compared to their 2D-cultured counterparts.

[Proceedings of the National Academy of Sciences of the United States of America] Investigators provided an insight into the developing adrenal gland and introduced the Schwann cell precursor gene signature as being of interest for further research in understanding neuroblastoma phenotype.

[Stem Cells] The neural crest (NC) is an ESC population that contributes to a greatly expanding list of derivatives ranging from neurons and glia of the peripheral nervous system, facial cartilage and bone, pigment cells of the skin to secretory cells of the endocrine system. Scientists focus on what is specifically known about establishment and maintenance of NC stemness and ultimate fate commitment mechanisms.

[Cell Reports] The authors identified an important role for oncogenic ALK-ERK1/2-SP1 signaling in the maintenance of undifferentiated neural crest-derived progenitors through the repression of DLG2, a candidate tumor suppressor gene in neuroblastoma.

[Scientific Reports] Researchers used a lentiviral chondroitinase ABC, capable of being secreted from mammalian cells, to examine the repercussions of chondroitin sulphate proteoglycans digestion upon Schwann cell behaviour in vitro.